Focal cortical dysplasia: neuropathological subtypes, EEG, neuroimaging and surgical outcome

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Focal cortical dysplasia: neuropathological subtypes, EEG, neuroimaging and surgical outcome.

Since the original description by Taylor, the term focal cortical dysplasia has been used to refer to a wide range of alterations of the cortical mantle. More recently, these conditions have been described from neuroimaging, neuropathological and genetic standpoints, generating several classifications. It is widely recognized that these classifications are unsatisfactory. We propose a simplifie...

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Neuroimaging of focal cortical dysplasia: neuropathological correlations.

Focal cortical dysplasia is a well-known cause of intractable epilepsy with early onset of seizures, and is potentially amenable to surgical therapy. It was first described by Taylor in 1971 as a peculiar malformative disorganisation of the neocortex characterised at histology by loss of cortical lamination and accompanied by giant, dysmorphic neurones and, most frequently, by "balloon cells" l...

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Comparison of MRI features and surgical outcome among the subtypes of focal cortical dysplasia

PURPOSE Focal cortical dysplasia (FCD) is the most common pathological diagnosis in patients who have undergone surgical treatment for intractable neocortical epilepsy. However, presurgical identification of MRI abnormalities in FCD patients remains difficult, and there are no highly sensitive imaging parameters available that can reliably differentiate among FCD subtypes. The purpose of our st...

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Stereo-EEG, radiofrequency thermocoagulation and neuropathological correlations in a patient with MRI-negative type IIb focal cortical dysplasia

Rita Garbelli *, Roberto Spreafico , Andrea Barbaglia , Laura Rossini , Gloria Milesi , Ileana Zucca , Massimo Cossu , Manuela Bramerio , Laura Tassi c Clinical Epileptology and Experimental Neurophysiology Unit, Fondazione IRCCS, Istituto Neurologico C. Besta, Milan, Italy b Scientific Department, Fondazione IRCCS, Istituto Neurologico C. Besta, Milan, Italy c ‘‘C Munari’’, Epilepsy Surgery Ce...

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Sleep influences the intracerebral EEG pattern of focal cortical dysplasia

OBJECTIVE Focal cortical dysplasia (FCD) is able to generate an intrinsic pathological EEG activity characterized by a continuous or near-continuous spiking. Different patterns of discharge were described. We examined quantitatively the distribution of the intracerebral FCD patterns in relation to sleep in order to investigate whether this activity is independent of thalamocortical influences. ...

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ژورنال

عنوان ژورنال: Brain

سال: 2002

ISSN: 1460-2156

DOI: 10.1093/brain/awf175